# Map brief — epigenetic clock reversal

Paste this whole thing. Nothing to fill in.

**Environment:** `night-shift-map`. The exact settings are on this mission's
page — the env file is the only place they live, so they cannot drift out of
sync with a copy written here.

---

## The job

A growing set of interventions in longevity research — partial cellular
reprogramming, plasmapheresis, and others — report a lower reading on an
"epigenetic clock" afterward, described as biological-age reversal. Critics
argue the clocks were never validated against a true measure of biological
age under these conditions, so a lower reading does not establish that
anything about aging was actually reversed, and may not track real
physiological improvement at all.

Lay out the specific validation gap the critique identifies, what the
proponent side — labs and longevity companies — claims the clock readings
show, and who has a commercial or reputational stake in each direction. This
is a field where nearly everyone qualified to adjudicate also sells a test or
runs a company on one side of the question; say so plainly wherever it's
true. Note which claims rest on published, peer-reviewed data and which rest
on results reported by a company that are not yet public.

## Sourcing rules

- Every claim about what someone said needs a citation: title, authors, year,
  link, and where in the document it appears (section, figure, page).
- **Open the page.** Do not cite from a search-result snippet. If a page will
  not load, say so explicitly and mark that citation as unverified rather than
  quietly using the snippet.
- Quote the sentence where each party states its position. One sentence is
  enough — do not reproduce passages.
- Where two sources conflict on a matter of fact (a date, a number, who did
  what), show both and say they conflict. Do not pick silently.
- If you cannot find a source for something you believe is true, leave it out.
- **"Blocked" and "paywalled" are different facts — say which.** A domain
  outside this environment's allowlist means you could not try. A domain that
  let you connect and then returned a paywall, login wall, or bot check means
  you tried and were refused. Both leave a gap in the record, but only the
  second tells the reader the source exists and is readable by someone else.
  For every source you could not read, the notes must say which of the two it
  was. Where a paywalled paper has a preprint, use the preprint and say you
  did.

## Output — two files, and both are required

**1. `output.md`** — the prose, as described above. Write it for a reader.
Structure it however reads best.

Then a section called **Notes on this run** — for me, not for a reader:
what you searched, what failed to load, which citations are unverified, what
you are unsure about, and anything that surprised you. Blunt.

**2. `positions.yaml`** — the same positions as structured data. One entry per
party per claim: a group that disputes two separate things gets two entries,
and two groups making the same claim get one entry each.

```yaml
positions_file:
  mission: MAP-011
  source: output.md
  count: <number of entries below>
positions:
  - id: P01
    party: <named person or group, as the source names them>
    claim: <one line, no hedging>
    stake: <employment, funding, or competition — factual, or "none found">
    sources:
      - url: <url>
        read: yes        # you opened this page and read the text you cite
      - url: <url>
        read: no         # you know it exists; you did not open it
```

**`read` is not a formality.** A URL you opened and a URL you merely know
exists are the same string, and listing one under `sources` implies you read
it. Say which. `read: yes` is checkable — an opened page leaves a fetch in
this session's transcript, which you do not write — so a `read: yes` with no
fetch behind it is a false record, and worth more scrutiny than an honest
`read: no`. Prefer citing what you read; where you must cite unread, say so
and the reader can weigh it.

**These must agree.** Every position in the prose appears in the YAML and vice
versa. The board counts entries in `positions.yaml` — it never parses your
prose, because a count derived from headings is a count that can silently be
wrong. If you can only produce one of the two files, produce neither and
deposit a finding explaining why.

An unmappable position is still a position: record it with the claim as stated
and `sources: []`, and say in the prose exactly what is missing.

## Where to put them

Push a branch to **`night-shift-network/inbox`** with both files inside a
directory named for this mission:

```
MAP-011/output.md
MAP-011/positions.yaml
```

The directory is what matters. A file at the root of the branch is not a
deposit and will not be collected — it will sit there looking delivered while
nothing has been.

The branch name does not matter and is deliberately not specified: the relay
reads every branch, so whichever branch your session is already on is fine.
Never delete or force-push a branch, yours or anyone else's; cleanup is
maintainer-side only.